FNDC4
Fibronectin type III domain-containing protein 4
Also known as: FLJ22362, FNDC4_HUMAN, FRCP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H6D8
- Gene
- FNDC4
- Ensembl
- ENSG00000115226
- Chromosome
- 2
- Canonical length
- 234 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Aggresome,Cytosol
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum; extracellular space; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
234 residues, UniProt reviewed canonical sequence.
>Q9H6D8|FNDC4
1 MPSGCHSSPP SGLRGDMASL VPLSPYLSPT VLLLVSCDLG FVRADRPPSP VNVTVTHLRA
61 NSATVSWDVP EGNIVIGYSI SQQRQNGPGQ RVIREVNTTT RACALWGLAE DSDYTVQVRS
121 IGLRGESPPG PRVHFRTLKG SDRLPSNSSS PGDITVEGLD GERPLQTGEV VIIVVVLLMW
181 AAVIGLFCRQ YDIIKDNDSN NNPKEKGKGP EQSPQGRPVG TRQKKSPSIN TIDVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FNDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 126 nTPM
Expression across tissuesHPA
Tissue
- liver: 126 nTPM
- adrenal gland: 125 nTPM
- cerebral cortex: 67 nTPM
- hippocampal formation: 56 nTPM
- basal ganglia: 50 nTPM
- amygdala: 48 nTPM
Single-cell type
- late spermatids: 1,057 nCPM
- esophageal apical cells: 417 nCPM
- early spermatids: 282 nCPM
- hepatocytes: 143 nCPM
- ovarian stromal cells: 72 nCPM
- late primary spermatocytes: 71 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 72 nTPM
- medulla oblongata: 64 nTPM
- pons: 62 nTPM
- cerebellum: 54 nTPM
- thalamus: 54 nTPM
- hippocampal formation: 52 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.88
- gnomAD missense Z
- 1.51
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FNDC4 as an antibody target. Whether an autoantibody or antibody against FNDC4 could matter depends on whether native FNDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FNDC4 is annotated as secreted, so native FNDC4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label FNDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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