Seroatlas · Human Serome Atlas

FNDC10

Fibronectin type III domain-containing protein 10

Also known as: C1orf233, FND10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
F2Z333
Gene
FNDC10
Ensembl
ENSG00000228594
Chromosome
1
Canonical length
226 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>F2Z333|FNDC10
     1  MRAPPLLLLL AACAPPPCAA AAPTPPGWEP TPDAPWCPYK VLPEGPEAGG GRLCFRSPAR
    61  GFRCQAPGCV LHAPAGRSLR ASVLRNRSVL LQWRLAPAAA RRVRAFALNC SWRGAYTRFP
   121  CERVLLGASC RDYLLPDVHD SVLYRLCLQP LPLRAGPAAA APETPEPAEC VEFTAEPAGM
   181  QDIVVAMTAV GGSICVMLVV ICLLVAYITE NLMRPALARP GLRRHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNDC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 28 nTPM
  • adrenal gland: 24 nTPM
  • cerebral cortex: 24 nTPM
  • amygdala: 18 nTPM
  • hippocampal formation: 18 nTPM
  • midbrain: 14 nTPM

Single-cell type

  • other brain neurons: 25 nCPM
  • gonadotrophs: 19 nCPM
  • undifferentiated spermatogonia: 18 nCPM
  • respiratory ionocytes: 15 nCPM
  • retinal amacrine cells: 15 nCPM
  • adrenal cortex cells: 14 nCPM

Immune cell

  • eosinophil: 1.6 nTPM
  • classical monocyte: 0.7 nTPM
  • myeloid DC: 0.7 nTPM
  • non-classical monocyte: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 53 nTPM
  • hypothalamus: 49 nTPM
  • medulla oblongata: 47 nTPM
  • pons: 43 nTPM
  • midbrain: 41 nTPM
  • hippocampal formation: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.12
DepMap mean gene effect
-0.1
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Fibronectin type III domain-containing protein 10
  • Fibronectin type III domain-containing protein 10

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNDC10 as an antibody target. Whether an autoantibody or antibody against FNDC10 could matter depends on whether native FNDC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNDC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNDC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FNDC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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