Seroatlas · Human Serome Atlas

FNBP4

Formin-binding protein 4

Also known as: FNBP4_HUMAN, KIAA1014

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3X1
Gene: FNBP4
Ensembl: ENSG00000109920
Chromosome: 11
Canonical length: 1017 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

1017 residues, UniProt reviewed canonical sequence.

>Q8N3X1|FNBP4
     1  MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA PSAATTTTTA
    61  VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA VKATGGLCLL GAYADSDDDD
   121  NDVSEKLAQS KETNGNQSTD IDSTLANFLA EIDAITAPQP AAPVGASAPP PTPPRPEPKE
   181  AATSTLSSST SNGTDSTQTS GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE
   241  VTWELPQYLA TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV
   301  KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE PVSEVKETST
   361  TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE EQDTLELELV LERKKAELRA
   421  LEEGDGSVSG SSPRSDISQP ASQDGMRRLM SKRGKWKMFV RATSPESTSR SSSKTGRDTP
   481  ENGETAIGAE NSEKIDENSD KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK
   541  FEFLGINRQS ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG
   601  WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT LKDKTGTDSN
   661  STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV PVLQPPLPLE MPPPPPPPPE
   721  SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI
   781  SSSSSTKGIK RKATEISTAV VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI
   841  PVSLPAAGMG HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA
   901  TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW QSIQRELDEE
   961  DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL PEDWRARLKR RKMAPNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 46 nTPM
spleen: 46 nTPM
ovary: 44 nTPM
cerebellum: 43 nTPM
cervix: 41 nTPM
thyroid gland: 39 nTPM

Single-cell type

microglia: 157 nCPM
podocytes: 154 nCPM
bergmann glia: 148 nCPM
oligodendrocytes: 147 nCPM
choroid plexus epithelial cells: 145 nCPM
oligodendrocyte progenitor cells: 145 nCPM

Immune cell

plasmacytoid DC: 5.6 nTPM
naive B-cell: 5.4 nTPM
memory B-cell: 5.1 nTPM
T-reg: 4 nTPM
basophil: 3.8 nTPM
gdT-cell: 3.7 nTPM

Brain region

cerebellum: 19 nTPM
choroid plexus: 16 nTPM
white matter: 14 nTPM
hypothalamus: 12 nTPM
thalamus: 12 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.54
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

WW domain
WW domain superfamily
WW domain
WW domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNBP4 as an antibody target. Whether an autoantibody or antibody against FNBP4 could matter depends on whether native FNBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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