FN3KRP

Protein identityUniProt · HPA

UniProt accession

Q9HA64

Gene

FN3KRP

Ensembl

ENSG00000141560

Chromosome

17

Canonical length

309 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9HA64|FN3KRP
     1  MEELLRRELG CSSVRATGHS GGGCISQGRS YDTDQGRVFV KVNPKAEARR MFEGEMASLT
    61  AILKTNTVKV PKPIKVLDAP GGGSVLVMEH MDMRHLSSHA AKLGAQLADL HLDNKKLGEM
   121  RLKEAGTVGR GGGQEERPFV ARFGFDVVTC CGYLPQVNDW QEDWVVFYAR QRIQPQMDMV
   181  EKESGDREAL QLWSALQLKI PDLFRDLEII PALLHGDLWG GNVAEDSSGP VIFDPASFYG
   241  HSEYELAIAG MFGGFSSSFY SAYHGKIPKA PGFEKRLQLY QLFHYLNHWN HFGSGYRGSS
   301  LNIMRNLVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FN3KRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

50 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

-0.33

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• post-translational protein modification

Molecular functions

• ATP binding
• kinase activity
• protein-ribulosamine 3-kinase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Protein kinase-like domain superfamily
• Fructosamine/Ketosamine-3-kinase
• Fructosamine kinase

KeywordsUniProt

• ATP-binding
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Transferase