Seroatlas · Human Serome Atlas

FMR1NB

FMR1 neighbor protein

Also known as: CT37, FLJ25736, FMR1N_HUMAN, NY-SAR-35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0W7
Gene: FMR1NB
Ensembl: ENSG00000176988
Chromosome: X
Canonical length: 255 aa
Protein class: Predicted membrane proteins
Subcellular location: Acrosome

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q8N0W7|FMR1NB
     1  MSSHRRKAKG RNRRSHRAMR VAHLELATYE LAATESNPES SHPGYEAAMA DRPQPGWRES
    61  LKMRVSKPFG MLMLSIWILL FVCYYLSYYL CSGSSYFVLA NGHILPNSEN AHGQSLEEDS
   121  ALEALLNFFF PTTCNLRENQ VAKPCNELQD LSESECLRHK CCFSSSGTTS FKCFAPFRDV
   181  PKQMMQMFGL GAISLILVCL PIYCRSLFWR SEPADDLQRQ DNRVVTGLKK QRRKRKRKSE
   241  MLQKAARGRE EHGDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FMR1NB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

testis: 57 nTPM
epididymis: 0.1 nTPM
liver: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early primary spermatocytes: 648 nCPM
differentiating spermatogonia: 294 nCPM
undifferentiated spermatogonia: 67 nCPM
late primary spermatocytes: 15 nCPM
late spermatids: 7.7 nCPM
early spermatids: 7.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
midbrain: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FMR1NB.

Disease | ImmuneIEDB

Conditions an epitope on FMR1NB was assayed in.

lung adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.08
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

FMR1 neighbor protein-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FMR1NB as an antibody target. Whether an autoantibody or antibody against FMR1NB could matter depends on whether native FMR1NB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FMR1NB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FMR1NB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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