Seroatlas · Human Serome Atlas

FMC1

Protein FMC1 homolog

Also known as: C7orf55, FMC1_HUMAN, HSPC268

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HJ9
Gene: FMC1
Ensembl: ENSG00000164898
Chromosome: 7
Canonical length: 113 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q96HJ9|FMC1
     1  MAALGSPSHT FRGLLRELRY LSAATGRPYR DTAAYRYLVK AFRAHRVTSE KLCRAQHELH
    61  FQAATYLCLL RSIRKHVALH QEFHGKGERS VEESAGLVGL KLPHQPGGKG WEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

tongue: 36 nTPM
skeletal muscle: 34 nTPM
heart muscle: 34 nTPM
choroid plexus: 23 nTPM
liver: 20 nTPM
kidney: 20 nTPM

Single-cell type

late primary spermatocytes: 559 nCPM
early spermatids: 114 nCPM
parietal cells: 106 nCPM
early primary spermatocytes: 62 nCPM
epididymal principal cells: 36 nCPM
epididymal efferent duct absorptive cells: 32 nCPM

Immune cell

memory B-cell: 25 nTPM
plasmacytoid DC: 21 nTPM
naive B-cell: 20 nTPM
T-reg: 17 nTPM
NK-cell: 16 nTPM
naive CD4 T-cell: 16 nTPM

Brain region

white matter: 13 nTPM
cerebellum: 10 nTPM
choroid plexus: 10 nTPM
medulla oblongata: 10 nTPM
basal ganglia: 9.8 nTPM
midbrain: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0.01
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Complex1_LYR-like
Protein FMC1 homologue

KeywordsUniProt

Mitochondrion

InteractionsUniProt · HPA

Protein binding partners of FMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATPAF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FMC1 as an antibody target. Whether an autoantibody or antibody against FMC1 could matter depends on whether native FMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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