Seroatlas · Human Serome Atlas

FLYWCH2

FLYWCH family member 2

Also known as: FWCH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CP2
Gene
FLYWCH2
Ensembl
ENSG00000162076
Chromosome
16
Canonical length
140 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q96CP2|FLYWCH2
     1  MPLPEPSEQE GESVKASQEP SPKPGTEVIP AAPRKPRKFS KLVLLTASKD STKVAGAKRK
    61  GVHCVMSLGV PGPATLAKAL LQTHPEAQRA IEAAPQEPEQ KRSRQDPGTD RTEDSGLAAG
   121  PPEAAGENFA PCSVAPGKSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLYWCH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 45 nTPM
  • cerebellum: 45 nTPM
  • hypothalamus: 44 nTPM
  • basal ganglia: 40 nTPM
  • midbrain: 37 nTPM
  • spleen: 35 nTPM

Single-cell type

  • oocytes: 189 nCPM
  • early primary spermatocytes: 139 nCPM
  • decidual stromal cells: 98 nCPM
  • esophageal apical cells: 78 nCPM
  • esophageal suprabasal cells: 77 nCPM
  • extravillous trophoblasts: 70 nCPM

Immune cell

  • plasmacytoid DC: 38 nTPM
  • non-classical monocyte: 29 nTPM
  • intermediate monocyte: 28 nTPM
  • myeloid DC: 28 nTPM
  • naive CD4 T-cell: 27 nTPM
  • T-reg: 25 nTPM

Brain region

  • medulla oblongata: 69 nTPM
  • pons: 60 nTPM
  • hypothalamus: 59 nTPM
  • midbrain: 55 nTPM
  • cerebellum: 54 nTPM
  • thalamus: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0.19
gnomAD missense Z
-0.09
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLYWCH2 as an antibody target. Whether an autoantibody or antibody against FLYWCH2 could matter depends on whether native FLYWCH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLYWCH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FLYWCH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FLYWCH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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