FLACC1
Flagellum-associated coiled-coil domain-containing protein 1
Also known as: ALS2CR12, FACC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96Q35
- Gene
- FLACC1
- Ensembl
- ENSG00000155749
- Chromosome
- 2
- Canonical length
- 445 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol,Connecting piece,Mid piece,Annulus
OverviewNCBI Gene
Predicted to be located in cytoplasmic vesicle and outer dense fiber. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
445 residues, UniProt reviewed canonical sequence.
>Q96Q35|FLACC1
1 MYPNPLIYCT CWDPWNLGPR KLIKTPQLPR KNSTGSSKLT PLVPAPKNHN YLQPTKPVVS
61 PKMKIHSARQ EETNKSFYEV INVSPGYQLV RNREQISVTL GDEMFDRKKR WESEIPDKGR
121 FSRTNIISDL EEQISELTAI IEQMNRDHQS AQKLLSSEMD LRCAEMKQNF ENKNRELKEA
181 HEAELSELEN NYKAALKAEK LAAQEKLEEM GKEYKYLKNM FRTYQDSIYD EMEEKWSKQK
241 AKWKKDEKFE RENILLQQKK KMTKKFEMES GEEDKKINES CSAVFENFIQ EKEELLKQHQ
301 SDTLQLEELR KTKEVPWRRD QINRHWHDVL QQLLLMQVMQ EELHAQALIL ESLNTNLYYT
361 QLELQKEKAI VGNLEKMLQT KFAETEEKYK HTIQILTEEN IHLKQKIISK NEEICEGCSG
421 RLASITVSKD DSDTVQDGSK KGQESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FLACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- testis: 16 nTPM
- choroid plexus: 8.5 nTPM
- fallopian tube: 7.8 nTPM
- bone marrow: 4.8 nTPM
- heart muscle: 4 nTPM
- retina: 3.1 nTPM
Single-cell type
- ependymal cells: 169 nCPM
- respiratory ciliated cells: 147 nCPM
- late primary spermatocytes: 124 nCPM
- early spermatids: 101 nCPM
- choroid plexus epithelial cells: 89 nCPM
- epididymal efferent duct ciliated cells: 87 nCPM
Immune cell
- neutrophil: 3.1 nTPM
- basophil: 2.9 nTPM
- NK-cell: 1.2 nTPM
- gdT-cell: 0.7 nTPM
- naive B-cell: 0.7 nTPM
- naive CD8 T-cell: 0.7 nTPM
Brain region
- choroid plexus: 28 nTPM
- midbrain: 20 nTPM
- medulla oblongata: 20 nTPM
- spinal cord: 16 nTPM
- hippocampal formation: 15 nTPM
- basal ganglia: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Flagellum-associated coiled-coil domain-containing protein 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FLACC1 as an antibody target. Whether an autoantibody or antibody against FLACC1 could matter depends on whether native FLACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FLACC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FLACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...