Seroatlas · Human Serome Atlas

FIZ1

Flt3-interacting zinc finger protein 1

Also known as: FIZ1_HUMAN, FLJ14768, ZNF798

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96SL8
Gene
FIZ1
Ensembl
ENSG00000179943
Chromosome
19
Canonical length
496 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q96SL8|FIZ1
     1  MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP HACPRCGKGF
    61  KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV HTGEKPYCCL VCELRFSSRS
   121  SLGRHLKRQH RGVLPSPLQP GPGLPALSAP CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG
   181  LGSWGLAEAA AAAAASLPPF ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP
   241  ALLERHKLTH DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG
   301  GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE AHSGPATYGC
   361  GHCGALYAAL AALEEHRRVS HGEGGGEEAA TAAREREPAS GEPPSGSGRG KKIFGCSECE
   421  KLFRSPRDLE RHVLVHTGEK PFPCLECGKF FRHECYLKRH RLLHGTERPF PCHICGKGFI
   481  TLSNLSRHLK LHRGMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 18 nTPM
  • cerebellum: 17 nTPM
  • basal ganglia: 16 nTPM
  • midbrain: 15 nTPM
  • spinal cord: 14 nTPM
  • hippocampal formation: 14 nTPM

Single-cell type

  • adrenal medulla cells: 21 nCPM
  • cardiomyocytes: 19 nCPM
  • adipocytes: 14 nCPM
  • retinal pigment epithelial cells: 13 nCPM
  • gastric progenitor cells: 12 nCPM
  • thymic myoid cells: 11 nCPM

Immune cell

  • plasmacytoid DC: 0.9 nTPM
  • intermediate monocyte: 0.7 nTPM
  • memory B-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • NK-cell: 0.5 nTPM
  • classical monocyte: 0.4 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • thalamus: 29 nTPM
  • basal ganglia: 27 nTPM
  • amygdala: 27 nTPM
  • midbrain: 25 nTPM
  • medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.53
gnomAD missense Z
3.5
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FIZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIZ1 as an antibody target. Whether an autoantibody or antibody against FIZ1 could matter depends on whether native FIZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FIZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FIZ1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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