Seroatlas · Human Serome Atlas

FITM2

Acyl-coenzyme A diphosphatase FITM2

Also known as: C20orf142, dJ881L22.2, FIT2, FITM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6M3
Gene
FITM2
Ensembl
ENSG00000197296
Chromosome
20
Canonical length
262 aa
Protein class
Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables coenzyme A diphosphatase activity. Involved in several processes, including fatty-acyl-CoA catabolic process; lipid droplet formation; and lipid homeostasis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Implicated in Siddiqi syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8N6M3|FITM2
     1  MEHLERCEWL LRGTLVRAAV RRYLPWALVA SMLAGSLLKE LSPLPESYLS NKRNVLNVYF
    61  VKVAWAWTFC LLLPFIALTN YHLTGKAGLV LRRLSTLLVG TAIWYICTSI FSNIEHYTGS
   121  CYQSPALEGV RKEHQSKQQC HQEGGFWHGF DISGHSFLLT FCALMIVEEM SVLHEVKTDR
   181  SHCLHTAITT LVVALGILTF IWVLMFLCTA VYFHNLSQKV FGTLFGLLSW YGTYGFWYPK
   241  AFSPGLPPQS CSLNLKQDSY KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FITM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 62 nTPM
  • tongue: 16 nTPM
  • parathyroid gland: 13 nTPM
  • adipose tissue: 11 nTPM
  • adrenal gland: 10 nTPM
  • skeletal muscle: 8.6 nTPM

Single-cell type

  • cardiomyocytes: 36 nCPM
  • parietal cells: 23 nCPM
  • adipocytes: 21 nCPM
  • pancreatic islet cells: 21 nCPM
  • alveolar cells type 1: 20 nCPM
  • enteric stem cells: 20 nCPM

Immune cell

  • naive CD4 T-cell: 2 nTPM
  • naive CD8 T-cell: 1.6 nTPM
  • NK-cell: 1.4 nTPM
  • MAIT T-cell: 1.2 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • T-reg: 1.2 nTPM

Brain region

  • pons: 19 nTPM
  • medulla oblongata: 18 nTPM
  • midbrain: 16 nTPM
  • choroid plexus: 16 nTPM
  • hypothalamus: 16 nTPM
  • cerebellum: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FITM2.

Disease | AllUniProt

Conditions FITM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Siddiqi syndrome
  • FITM2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FITM2 as an antibody target. Whether an autoantibody or antibody against FITM2 could matter depends on whether native FITM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FITM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FITM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FITM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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