Seroatlas · Human Serome Atlas

FITM1

Fat storage-inducing transmembrane protein 1

Also known as: FIT1, FITM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5D6W6
Gene: FITM1
Ensembl: ENSG00000139914
Chromosome: 14
Canonical length: 292 aa
Protein class: Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable diacylglycerol binding activity and triglyceride binding activity. Predicted to be involved in fat cell differentiation; lipid droplet formation; and phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>A5D6W6|FITM1
     1  MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP CLRRLYHAWL
    61  AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC TFLGGFVLLV VFLATRRVAV
   121  TARHLSRLVV GAAVWRGAGR AFLLIEDLTG SCFEPLPQGL LLHELPDRRS CLAAGHQWRG
   181  YTVSSHTFLL TFCCLLMAEE AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV
   241  IYFHQYTHKV VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FITM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 218 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 218 nTPM
heart muscle: 164 nTPM
liver: 26 nTPM
pancreas: 15 nTPM
spleen: 9.5 nTPM
salivary gland: 7 nTPM

Single-cell type

astrocytes: 1.7 nCPM
thymic myoid cells: 1.4 nCPM
proximal tubule cells: 1.1 nCPM
renal connecting tubule cells: 1.1 nCPM
choroid plexus epithelial cells: 0.8 nCPM
ependymal cells: 0.7 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
cerebral cortex: 1.4 nTPM
white matter: 1.4 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM
amygdala: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Fat storage-inducing transmembrane protein
Fat storage-inducing transmembrane protein 1/2
Fat storage-inducing transmembrane protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FITM1 as an antibody target. Whether an autoantibody or antibody against FITM1 could matter depends on whether native FITM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FITM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FITM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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