Seroatlas · Human Serome Atlas

FIMP

Fertilization-influencing membrane protein

Also known as: C16orf92, FIMP_HUMAN, FLJ25404

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LL3
Gene
FIMP
Ensembl
ENSG00000167194
Chromosome
16
Canonical length
132 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q96LL3|FIMP
     1  MGAGVGVAGC TRGHRNWVPS QLPPREIKAG VSLAVVTEFA WVLAPRPKRA TASALGTESP
    61  RFLDRPDFFD YPDSDQARLL AVAQFIGEKP IVFINSGSSP GLFHHILVGL LVVAFFFLLF
   121  QFCTHINFQK GA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • retina: 33 nTPM
  • testis: 15 nTPM
  • cerebral cortex: 1.8 nTPM
  • adrenal gland: 1.2 nTPM
  • cerebellum: 1 nTPM
  • hippocampal formation: 0.5 nTPM

Single-cell type

  • early spermatids: 132 nCPM
  • late primary spermatocytes: 59 nCPM
  • late spermatids: 50 nCPM
  • cone photoreceptor cells: 15 nCPM
  • rod photoreceptor cells: 11 nCPM
  • retinal ganglion cells: 7.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 7.8 nTPM
  • pons: 6.1 nTPM
  • hippocampal formation: 5.6 nTPM
  • basal ganglia: 5.1 nTPM
  • white matter: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0.03
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Fertilization-influencing membrane protein
  • Fertilisation-influencing membrane protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIMP as an antibody target. Whether an autoantibody or antibody against FIMP could matter depends on whether native FIMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIMP is annotated at the cell surface, where native FIMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FIMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FIMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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