Seroatlas · Human Serome Atlas

FILIP1L

Filamin A-interacting protein 1-like

Also known as: DOC-1, FIL1L_HUMAN, GIP130

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4L180
Gene: FILIP1L
Ensembl: ENSG00000168386
Chromosome: 3
Canonical length: 1135 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be involved in protein localization to actin cytoskeleton. Predicted to act upstream of or within several processes, including hindgut development; proteasomal protein catabolic process; and protein secretion. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in actin cytoskeleton and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1135 residues, UniProt reviewed canonical sequence.

>Q4L180|FILIP1L
     1  MRSRGSDTEG SAQKKFPRHT KGHSFQGPKN MKHRQQDKDS PSESDVILPC PKAEKPHSGN
    61  GHQAEDLSRD DLLFLLSILE GELQARDEVI GILKAEKMDL ALLEAQYGFV TPKKVLEALQ
   121  RDAFQAKSTP WQEDIYEKPM NELDKVVEKH KESYRRILGQ LLVAEKSRRQ TILELEEEKR
   181  KHKEYMEKSD EFICLLEQEC ERLKKLIDQE IKSQEEKEQE KEKRVTTLKE ELTKLKSFAL
   241  MVVDEQQRLT AQLTLQRQKI QELTTNAKET HTKLALAEAR VQEEEQKATR LEKELQTQTT
   301  KFHQDQDTIM AKLTNEDSQN RQLQQKLAAL SRQIDELEET NRSLRKAEEE LQDIKEKISK
   361  GEYGNAGIMA EVEELRKRVL DMEGKDEELI KMEEQCRDLN KRLERETLQS KDFKLEVEKL
   421  SKRIMALEKL EDAFNKSKQE CYSLKCNLEK ERMTTKQLSQ ELESLKVRIK ELEAIESRLE
   481  KTEFTLKEDL TKLKTLTVMF VDERKTMSEK LKKTEDKLQA ASSQLQVEQN KVTTVTEKLI
   541  EETKRALKSK TDVEEKMYSV TKERDDLKNK LKAEEEKGND LLSRVNMLKN RLQSLEAIEK
   601  DFLKNKLNQD SGKSTTALHQ ENNKIKELSQ EVERLKLKLK DMKAIEDDLM KTEDEYETLE
   661  RRYANERDKA QFLSKELEHV KMELAKYKLA EKTETSHEQW LFKRLQEEEA KSGHLSREVD
   721  ALKEKIHEYM ATEDLICHLQ GDHSVLQKKL NQQENRNRDL GREIENLTKE LERYRHFSKS
   781  LRPSLNGRRI SDPQVFSKEV QTEAVDNEPP DYKSLIPLER AVINGQLYEE SENQDEDPND
   841  EGSVLSFKCS QSTPCPVNRK LWIPWMKSKE GHLQNGKMQT KPNANFVQPG DLVLSHTPGQ
   901  PLHIKVTPDH VQNTATLEIT SPTTESPHSY TSTAVIPNCG TPKQRITILQ NASITPVKSK
   961  TSTEDLMNLE QGMSPITMAT FARAQTPESC GSLTPERTMS PIQVLAVTGS ASSPEQGRSP
  1021  EPTEISAKHA IFRVSPDRQS SWQFQRSNSN SSSVITTEDN KIHIHLGSPY MQAVASPVRP
  1081  ASPSAPLQDN RTQGLINGAL NKTTNKVTSS ITITPTATPL PRQSQITVEP LLLPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FILIP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 191 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 191 nTPM
smooth muscle: 141 nTPM
endometrium: 108 nTPM
urinary bladder: 95 nTPM
skeletal muscle: 89 nTPM
tongue: 89 nTPM

Single-cell type

myonuclei: 5,256 nCPM
late spermatids: 2,462 nCPM
epicardial cells: 1,044 nCPM
early spermatids: 931 nCPM
vascular smooth muscle cells: 639 nCPM
cardiomyocytes: 572 nCPM

Immune cell

non-classical monocyte: 3 nTPM
myeloid DC: 2.1 nTPM
intermediate monocyte: 1 nTPM
naive B-cell: 0.6 nTPM
memory B-cell: 0.5 nTPM
classical monocyte: 0.4 nTPM

Brain region

pons: 20 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM
cerebellum: 12 nTPM
midbrain: 11 nTPM
basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to actin cytoskeleton

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FILIP1L as an antibody target. Whether an autoantibody or antibody against FILIP1L could matter depends on whether native FILIP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FILIP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FILIP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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