Seroatlas · Human Serome Atlas

FICD

Protein adenylyltransferase FICD

Also known as: FICD_HUMAN, HIP13, HYPE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVA6
Gene
FICD
Ensembl
ENSG00000198855
Chromosome
12
Canonical length
458 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including AMPylase activity; ATP binding activity; and Hsp70 protein binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q9BVA6|FICD
     1  MMLIPMASVM AVTEPKWVSV WSRFLWVTLL SMVLGSLLAL LLPLGAVEEQ CLAVLKGLYL
    61  LRSKPDRAQH AATKCTSPST ELSITSRGAT LLVAKTKASP AGKLEARAAL NQALEMKRQG
   121  KREKAQKLFM HALKMDPDFV DALTEFGIFS EEDKDIIQAD YLYTRALTIS PYHEKALVNR
   181  DRTLPLVEEI DQRYFSIIDS KVKKVMSIPK GNSALRRVME ETYYHHIYHT VAIEGNTLTL
   241  SEIRHILETR YAVPGKSLEE QNEVIGMHAA MKYINTTLVS RIGSVTISDV LEIHRRVLGY
   301  VDPVEAGRFR TTQVLVGHHI PPHPQDVEKQ MQEFVQWLNS EEAMNLHPVE FAALAHYKLV
   361  YIHPFIDGNG RTSRLLMNLI LMQAGYPPIT IRKEQRSDYY HVLEAANEGD VRPFIRFIAK
   421  CTETTLDTLL FATTEYSVAL PEAQPNHSGF KETLPVKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FICD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 12 nTPM
  • epididymis: 12 nTPM
  • pituitary gland: 11 nTPM
  • thyroid gland: 10 nTPM
  • salivary gland: 8.4 nTPM
  • liver: 7.9 nTPM

Single-cell type

  • early spermatids: 88 nCPM
  • late spermatids: 76 nCPM
  • retinal pigment epithelial cells: 73 nCPM
  • epididymal principal cells: 57 nCPM
  • syncytiotrophoblasts: 46 nCPM
  • plasma cells: 45 nCPM

Immune cell

  • plasmacytoid DC: 15 nTPM
  • basophil: 12 nTPM
  • MAIT T-cell: 7.7 nTPM
  • gdT-cell: 6.3 nTPM
  • memory CD8 T-cell: 5.9 nTPM
  • non-classical monocyte: 5.9 nTPM

Brain region

  • white matter: 14 nTPM
  • medulla oblongata: 13 nTPM
  • midbrain: 13 nTPM
  • hypothalamus: 12 nTPM
  • spinal cord: 12 nTPM
  • thalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FICD.

Disease | AllUniProt

Conditions FICD is implicated in, by any mechanism.

  • Spastic paraplegia 92, autosomal recessive (SPG92) MIM:620911

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spastic paraplegia 92, autosomal recessive

Disease | ImmuneIEDB

Conditions an epitope on FICD was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0.01
gnomAD missense Z
0.31
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FICD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FICD as an antibody target. Whether an autoantibody or antibody against FICD could matter depends on whether native FICD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FICD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FICD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FICD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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