Seroatlas · Human Serome Atlas

FIBIN

Fin bud initiation factor homolog

Also known as: FIBIN_HUMAN, MGC24932

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAL6
Gene: FIBIN
Ensembl: ENSG00000176971
Chromosome: 11
Canonical length: 211 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable protein homodimerization activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q8TAL6|FIBIN
     1  MVFLKFFCMS FFCHLCQGYF DGPLYPEMSN GTLHHYFVPD GDYEENDDPE KCQLLFRVSD
    61  HRRCSQGEGS QVGSLLSLTL REEFTVLGRQ VEDAGRVLEG ISKSISYDLD GEESYGKYLR
   121  RESHQIGDAY SNSDKSLTEL ESKFKQGQEQ DSRQESRLNE DFLGMLVHTR SLLKETLDIS
   181  VGLRDKYELL ALTIRSHGTR LGRLKNDYLK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIBIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 121 nTPM
seminal vesicle: 58 nTPM
vagina: 39 nTPM
ovary: 34 nTPM
cervix: 24 nTPM
adipose tissue: 23 nTPM

Single-cell type

hepatic stellate cells: 110 nCPM
fibroblasts: 88 nCPM
oligodendrocyte progenitor cells: 38 nCPM
peritubular myoid cells: 37 nCPM
ovarian stromal cells: 33 nCPM
thymic myoid cells: 29 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 17 nTPM
thalamus: 15 nTPM
medulla oblongata: 15 nTPM
white matter: 14 nTPM
cerebellum: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.42
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fin bud initiation factor
Fin bud initiation factor homologue

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIBIN as an antibody target. Whether an autoantibody or antibody against FIBIN could matter depends on whether native FIBIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIBIN is annotated as secreted, so native FIBIN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FIBIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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