Seroatlas · Human Serome Atlas

FHIP2B

FHF complex subunit HOOK-interacting protein 2B

Also known as: FAM160B2, FHI2B_HUMAN, FLJ21801, RAI16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V87
Gene: FHIP2B
Ensembl: ENSG00000158863
Chromosome: 8
Canonical length: 743 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for FHIP2B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

743 residues, UniProt reviewed canonical sequence.

>Q86V87|FHIP2B
     1  MLSRLGALLQ EAVGAREPSI DLLQAFVEHW KGITHYYIES TDESTPAKKT DIPWRLKQML
    61  DILVYEEQQQ AAAGEAGPCL EYLLQHKILE TLCTLGKAEY PPGMRQQVFQ FFSKVLAQVQ
   121  HPLLHYLSVH RPVQKLLRLG GTASGSVTEK EEVQFTTVLC SKIQQDPELL AYILEGKKIV
   181  GRKKACGEPT ALPKDTTSHG DKDCSHDGAP ARPQLDGESC GAQALNSHMP AETEELDGGT
   241  TESNLITSLL GLCQSKKSRV ALKAQENLLL LVSMASPAAA TYLVQSSACC PAIVRHLCQL
   301  YRSMPVFLDP ADIATLEGIS WRLPSAPSDE ASFPGKEALA AFLGWFDYCD HLITEAHTVV
   361  ADALAKAVAE NFFVETLQPQ LLHVSEQSIL TSTALLTAML RQLRSPALLR EAVAFLLGTD
   421  RQPEAPGDNP HTLYAHLIGH CDHLSDEISI TTLRLFEELL QKPHEGIIHS LVLRNLEGRP
   481  YVAWGSPEPE SYEDTLDLEE DPYFTDSFLD SGFQTPAKPR LAPATSYDGK TAVTEIVNSF
   541  LCLVPEEAKT SAFLEETGYD TYVHDAYGLF QECSSRVASW GWPLTPTPLD PHEPERPFFE
   601  GHFLRVLFDR MSRILDQPYS LNLQVTSVLS RLALFPHPHI HEYLLDPYIS LAPGCRSLFS
   661  VLVRVIGDLM QRIQRVPQFP GKLLLVRKQL TGQAPGEQLD HQTLLQGVVV LEEFCKELAA
   721  IAFVKFPPHD PRQNVSPAPE GQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FHIP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pancreas: 21 nTPM
heart muscle: 20 nTPM
blood vessel: 17 nTPM
urinary bladder: 17 nTPM
skeletal muscle: 17 nTPM
stomach: 16 nTPM

Single-cell type

breast lactating cells: 48 nCPM
adipocytes: 43 nCPM
salivary duct cells: 35 nCPM
papillary tip epithelial cells: 31 nCPM
gonadotrophs: 28 nCPM
fibro-adipogenic progenitors: 28 nCPM

Immune cell

gdT-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
total PBMC: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM

Brain region

medulla oblongata: 17 nTPM
thalamus: 16 nTPM
amygdala: 16 nTPM
cerebral cortex: 16 nTPM
white matter: 15 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FHIP2B as an antibody target. Whether an autoantibody or antibody against FHIP2B could matter depends on whether native FHIP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FHIP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FHIP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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