FHIP2A

Protein identityUniProt · HPA

UniProt accession

Q5W0V3

Gene

FHIP2A

Ensembl

ENSG00000151553

Chromosome

10

Canonical length

765 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for FHIP2A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q5W0V3|FHIP2A
     1  MFSKFTSILQ HAVEALAPSL PLQEDFVYHW KAITHYYIET SDDKAPVTDT NIPSHLEQML
    61  DILVQEENER ESGETGPCME YLLHHKILET LYTLGKADCP PGMKQQVLVF YTKLLGRIRQ
   121  PLLPHINVHR PVQKLIRLCG EVLATPTENE EIQFLCIVCA KLKQDPYLVN FFLENKMKSL
   181  ASKGVPNVIS EDTLKGQDSL STDTGQSRQP EELSGATGME QTELEDEPPH QMDHLSTSLD
   241  NLSVTSLPEA SVVCPNQDYN LVNSLLNLTR SPDGRIAVKA CEGLMLLVSL PEPAAAKCLT
   301  QSTCLCELLT DRLASLYKAL PQSVDPLDIE TVEAINWGLD SYSHKEDASA FPGKRALISF
   361  LSWFDYCDQL IKEAQKTAAV ALAKAVHERF FIGVMEPQLM QTSEMGILTS TALLHRIVRQ
   421  VTSDVLLQEM VFFILGEQRE PETLAEISRH PLRHRLIEHC DHISDEISIM TLRMFEHLLQ
   481  KPNEHILYNL VLRNLEERNY TEYKPLCPED KDVVENGLIA GAVDLEEDPL FTDISPENTL
   541  PNQEWLSSSP PATPDHPKND GKTEVHKIVN SFLCLVPDDA KSSYHVEGTG YDTYLRDAHR
   601  QFRDYCAICL RWEWPGSPKA LEKCNLEAAF FEGHFLKVLF DRMGRILDQP YDVNLQVTSV
   661  LSRLSLFPHP HIHEYLLDPY VNLAPGCRSL FSVIVRVVGD LMLRIQRIQD FTPKLLLVRK
   721  RLLGLEPEGP IIDHITLLEG VIVLEEFCKE LAAIAFVKYH ASSTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FHIP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

50 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FHIP2A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Syndromic intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

• FHF complex subunit HOOK interacting protein
• FHF complex subunit HOOK-interacting protein, KELAA motif
• FHF complex subunit HOOK-interacting protein, C-terminal
• Retinoic acid induced 16-like protein
• KELAA motif
• Family of unknown function (DUF5917)

InteractionsUniProt · HPA

Protein binding partners of FHIP2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HOOK2