Seroatlas · Human Serome Atlas

FHAD1

Forkhead-associated domain-containing protein 1

Also known as: FHAD1_HUMAN, KIAA1937

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B1AJZ9
Gene: FHAD1
Ensembl: ENSG00000142621
Chromosome: 1
Canonical length: 1412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to act upstream of or within apoptotic process and spermatogenesis. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1412 residues, UniProt reviewed canonical sequence.

>B1AJZ9|FHAD1
     1  MKAYLKSAEG FFVLNKSTTI GRHENSDLVL QSPDIDNHHA LIEYNEAECS FVLQDFNSRN
    61  GTFVNECHIQ NVAVKLIPGD ILRFGSAGLT YELVIENPPP VSFPWMRGPA PWPGPQPPRA
   121  TQQPNQAPPP SHIPFHQGVQ PAPMQRSWSQ AFPRPTVVLP ASHRRPVSAN KEMFSFVVDD
   181  ARKPPVIKQV WTNAMKLSEK SVAEGIPGAV PPAEIYVEED LAQQDKDEII LLLGKEVSRL
   241  SDYEIESKYK DVIIANLQNE VAELSQKVSE TTTSRQNEKE ISQKCQVLDE DIDAKQKEIQ
   301  SLKSQISALQ KGYSKVLCQT LSERNSEITS LKNEGENLKR DNAITSGMVS SLQKDILAKD
   361  EQVQQLKEEV SHLKSQNKDK DHQLEALGSR CSVLKEELKQ EDAHRELREA QEKELKLCKT
   421  QIQDMEKEMK KLRAELRKSC TEQSVISRTL REKSKVEEKL QEDSRRKLLQ LQEMGNRESV
   481  IKINLERAVG QLEHFRSQVI KATYGRAKPF RDKPVTDQQL IEKITQVTED NINFQQKKWT
   541  LQKETQLSNS KQEETTENIE KLRTSLDSCQ ACMKISCCSH DLKKEVDLLQ HLQVSPPVSG
   601  LQKVVLDVLR HALSWLEEVE QLLRDLGILP SSPNKDQVQQ FSGNSAVFTA GKAAGASGRE
   661  GEAERGEARA RGEAQSQNQA TDGREGGKAL EEYITQERNR AKETLEEERK RMQELESLLA
   721  QQKKALAKSI TQEKNRVKEA LEEEQTRVQE LEERLARQKE VLESSIAHEK RKAKEALESE
   781  KRKVQDLENH LTQQKEISES NIAYEKRKAK EAMEKEKKKV QDLENRLTKQ KEELELKEQK
   841  EDVLNNKLSD ALAMVEETQK TKATESLKAE SLALKLNETL AELETTKTKM IMVEERLILQ
   901  QKMVKALQDE QESQRHGFEE EIMEYKEQIK QHAQTIVSLE EKLQKVTQHH KKIEGEIATL
   961  KDNDPAPKEE RPQDPLVAPM TESSAKDMAY EHLIDDLLAA QKEILSQQEV IMKLRKDLTE
  1021  AHSRMSDLRG ELNEKQKMEL EQNVVLVQQQ SKELSVLKEK MAQMSSLVEK KDRELKALEE
  1081  ALRASQEKHR LQLNTEKEQK PRKKTQTCDT SVQIEPVHTE AFSSSQEQQS FSDLGVRCKG
  1141  SRHEEVIQRQ KKALSELRAR IKELEKARSP DHKDHQNESF LDLKNLRMEN NVQKILLDAK
  1201  PDLPTLSRIE ILAPQNGLCN ARFGSAMEKS GKMDVAEALE LSEKLYLDMS KTLGSLMNIK
  1261  NMSGHVSMKY LSRQEREKVN QLRQRDLDLV FDKITQLKNQ LGRKEELLRG YEKDVEQLRR
  1321  SKVSIEMYQS QVAKLEDDIY KEAEEKALLK EALERMEHQL CQEKRINRAI RQQKVGTRKA
  1381  SLKMDQEREM LRKETSSKSS QSLLHSKPSG KY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FHAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 15 nTPM
testis: 13 nTPM
choroid plexus: 9.9 nTPM
lung: 3.4 nTPM
cervix: 2.2 nTPM
stomach: 2.1 nTPM

Single-cell type

respiratory ciliated cells: 681 nCPM
late spermatids: 616 nCPM
ependymal cells: 464 nCPM
endometrial ciliated cells: 460 nCPM
early spermatids: 450 nCPM
epididymal efferent duct ciliated cells: 417 nCPM

Immune cell

gdT-cell: 0.9 nTPM
classical monocyte: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

choroid plexus: 33 nTPM
midbrain: 21 nTPM
medulla oblongata: 12 nTPM
pons: 8.9 nTPM
spinal cord: 7.6 nTPM
hippocampal formation: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

sperm flagellum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FHAD1 as an antibody target. Whether an autoantibody or antibody against FHAD1 could matter depends on whether native FHAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FHAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FHAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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