Seroatlas · Human Serome Atlas

FGL1

Fibrinogen-like protein 1

Also known as: FGL1_HUMAN, HFREP-1, HPS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08830
Gene: FGL1
Ensembl: ENSG00000104760
Chromosome: 8
Canonical length: 312 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q08830|FGL1
     1  MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV
    61  QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW
   121  TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE
   181  KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD
   241  HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
   301  KIRPNDFIPN VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 3,863 nTPM

Expression across tissuesHPA

Tissue

liver: 3,863 nTPM
pancreas: 623 nTPM
placenta: 5.9 nTPM
testis: 4 nTPM
prostate: 3.3 nTPM
spleen: 3.2 nTPM

Single-cell type

hepatocytes: 7,991 nCPM
pancreatic acinar cells: 662 nCPM
hofbauer cells: 273 nCPM
cholangiocytes: 227 nCPM
microglia: 152 nCPM
kupffer cells: 134 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.7 nTPM
hypothalamus: 1.7 nTPM
pons: 1.7 nTPM
thalamus: 1.6 nTPM
basal ganglia: 1.4 nTPM
hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -2.72
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGL1 as an antibody target. Whether an autoantibody or antibody against FGL1 could matter depends on whether native FGL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGL1 is annotated as secreted, so native FGL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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