Seroatlas · Human Serome Atlas

FGFRL1

Fibroblast growth factor receptor-like 1

Also known as: FGRL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N441
Gene: FGFRL1
Ensembl: ENSG00000127418
Chromosome: 4
Canonical length: 504 aa
Protein class: Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q8N441|FGFRL1
     1  MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL
    61  TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI
   121  SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP
   181  DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ
   241  RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG
   301  QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK
   361  PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP
   421  GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT
   481  HTHTHSHTHS HVEGKVHQHI HYQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGFRL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

pancreas: 68 nTPM
thyroid gland: 64 nTPM
adrenal gland: 52 nTPM
liver: 50 nTPM
blood vessel: 47 nTPM
basal ganglia: 43 nTPM

Single-cell type

müller glia: 96 nCPM
retinal pigment epithelial cells: 43 nCPM
extravillous trophoblasts: 42 nCPM
hepatocytes: 40 nCPM
breast lactating cells: 32 nCPM
pancreatic acinar cells: 31 nCPM

Immune cell

non-classical monocyte: 1.2 nTPM
intermediate monocyte: 1.1 nTPM
basophil: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM

Brain region

medulla oblongata: 68 nTPM
thalamus: 62 nTPM
midbrain: 59 nTPM
basal ganglia: 52 nTPM
spinal cord: 52 nTPM
cerebral cortex: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.01
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGFRL1 as an antibody target. Whether an autoantibody or antibody against FGFRL1 could matter depends on whether native FGFRL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGFRL1 is annotated at the cell surface, where native FGFRL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FGFRL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...