Seroatlas · Human Serome Atlas

FGFBP2

Fibroblast growth factor-binding protein 2

Also known as: FGFP2_HUMAN, KSP37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYJ0
Gene: FGFBP2
Ensembl: ENSG00000137441
Chromosome: 4
Canonical length: 223 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq, Jan 2025]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9BYJ0|FGFBP2
     1  MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR
    61  VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA
   121  GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR
   181  PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGFBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 51 nTPM
adipose tissue: 28 nTPM
heart muscle: 24 nTPM
skin: 21 nTPM
spleen: 13 nTPM
breast: 13 nTPM

Single-cell type

nk-cells: 326 nCPM
schwann cells: 112 nCPM
melanocytes: 96 nCPM
t-cells: 38 nCPM
fibroblasts: 17 nCPM
granulosa cells: 11 nCPM

Immune cell

gdT-cell: 553 nTPM
total PBMC: 371 nTPM
memory CD8 T-cell: 332 nTPM
naive CD8 T-cell: 315 nTPM
memory CD4 T-cell: 129 nTPM
NK-cell: 65 nTPM

Brain region

hippocampal formation: 0.7 nTPM
hypothalamus: 0.7 nTPM
basal ganglia: 0.6 nTPM
medulla oblongata: 0.5 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGFBP2 as an antibody target. Whether an autoantibody or antibody against FGFBP2 could matter depends on whether native FGFBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGFBP2 is annotated as secreted, so native FGFBP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGFBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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