Seroatlas · Human Serome Atlas

FFAR3

Free fatty acid receptor 3

Also known as: FFA3R, FFAR3_HUMAN, GPR41

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14843
Gene: FFAR3
Ensembl: ENSG00000185897
Chromosome: 19
Canonical length: 346 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O14843|FFAR3
     1  MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLQRRPVAV DVLLLNLTAS
    61  DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP
   121  LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI
   181  LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLLAAT LLNFLVCFGP
   241  YNVSHVVGYI CGESPAWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
   301  WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FFAR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 3.8 nTPM
appendix: 2.4 nTPM
breast: 2.2 nTPM
smooth muscle: 1.5 nTPM
colon: 1.2 nTPM
spleen: 1.1 nTPM

Single-cell type

mast cells: 8.8 nCPM
monocytes: 4.9 nCPM
innate lymphoid cells: 4.2 nCPM
kupffer cells: 3.1 nCPM
neutrophils: 2.5 nCPM
pancreatic islet cells: 2.5 nCPM

Immune cell

neutrophil: 2.8 nTPM
eosinophil: 2.5 nTPM
intermediate monocyte: 0.5 nTPM
non-classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 2.1 nTPM
white matter: 1.9 nTPM
midbrain: 0.8 nTPM
basal ganglia: 0.7 nTPM
cerebral cortex: 0.7 nTPM
choroid plexus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FFAR3 as an antibody target. Whether an autoantibody or antibody against FFAR3 could matter depends on whether native FFAR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FFAR3 is annotated at the cell surface, where native FFAR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FFAR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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