Seroatlas · Human Serome Atlas

FFAR2

Free fatty acid receptor 2

Also known as: FFA2R, FFAR2_HUMAN, GPR43

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15552
Gene: FFAR2
Ensembl: ENSG00000126262
Chromosome: 19
Canonical length: 330 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>O15552|FFAR2
     1  MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS LTLADLLLLL
    61  LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL AGISIERYLG VAFPVQYKLS
   121  RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL NTTEQVRSGN EITCYENFTD NQLDVVLPVR
   181  LELCLVLFFI PMAVTIFCYW RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV
   241  SHLVGYHQRK SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG
   301  RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FFAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
bone marrow: 19 nTPM
appendix: 17 nTPM
lung: 7.3 nTPM
urinary bladder: 5.6 nTPM
adipose tissue: 4.6 nTPM

Single-cell type

neutrophils: 314 nCPM
monocytes: 41 nCPM
neuroendocrine cells: 32 nCPM
kupffer cells: 27 nCPM
monocyte progenitors: 18 nCPM
goblet cells: 15 nCPM

Immune cell

neutrophil: 250 nTPM
eosinophil: 85 nTPM
non-classical monocyte: 6.5 nTPM
intermediate monocyte: 5.6 nTPM
basophil: 3.1 nTPM
classical monocyte: 2.1 nTPM

Brain region

white matter: 2.6 nTPM
choroid plexus: 2 nTPM
cerebral cortex: 1.9 nTPM
medulla oblongata: 1.9 nTPM
basal ganglia: 1.8 nTPM
thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.01
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FFAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FCN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FFAR2 as an antibody target. Whether an autoantibody or antibody against FFAR2 could matter depends on whether native FFAR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FFAR2 is annotated at the cell surface, where native FFAR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FFAR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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