Seroatlas · Human Serome Atlas

FEZF2

Fez family zinc finger protein 2

Also known as: FEZF2_HUMAN, FEZL, FKSG36, FLJ10142, TOF, Zfp312, ZNF312

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBJ5
Gene
FEZF2
Ensembl
ENSG00000153266
Chromosome
3
Canonical length
459 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q8TBJ5|FEZF2
     1  MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP GALEADGSQG
    61  KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSELWKSSLR AGGGGGGGGG GGGGGGGAPV
   121  CGASGLCKTN CGVCCKAELG LAPSALPAGR VIKPQVINQA VGLPASGSLY YFNYLDSTAY
   181  PPSELLSGHL FPSGLLNAQA PAALAAHPKL FLLENAKLAG LAADKFPHPA PYPHKERLPA
   241  PLEQVLKENS ALTAERGGVK GHSKLPGGSA DGKPKNFTCE VCGKVFNAHY NLTRHMPVHT
   301  GARPFVCKVC GKGFRQASTL CRHKIIHTQE KPHKCNQCGK AFNRSSTLNT HIRIHAGYKP
   361  FVCEFCGKGF HQKGNYKNHK LTHSGEKQYK CTICNKAFHQ VYNLTFHMHT HNDKKPFTCA
   421  TCGKGFCRNF DLKKHVRKLH DSVGPAAPSA KDLTRTVQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FEZF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 26 nTPM
  • cerebral cortex: 18 nTPM
  • amygdala: 15 nTPM
  • basal ganglia: 5.6 nTPM
  • retina: 5.3 nTPM
  • thymus: 2.6 nTPM

Single-cell type

  • retinal bipolar cells: 42 nCPM
  • oocytes: 14 nCPM
  • brain excitatory neurons: 8.7 nCPM
  • astrocytes: 8.3 nCPM
  • pituicytes/fscs: 1.7 nCPM
  • müller glia: 1.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 330 nTPM
  • hippocampal formation: 115 nTPM
  • white matter: 35 nTPM
  • medulla oblongata: 32 nTPM
  • basal ganglia: 25 nTPM
  • pons: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FEZF2.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
2.07
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FEZF2 as an antibody target. Whether an autoantibody or antibody against FEZF2 could matter depends on whether native FEZF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FEZF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FEZF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FEZF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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