FETUB
Fetuin-B
Also known as: FETUB_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UGM5
- Gene
- FETUB
- Ensembl
- ENSG00000090512
- Chromosome
- 3
- Canonical length
- 382 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Vesicles
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
382 residues, UniProt reviewed canonical sequence.
>Q9UGM5|FETUB
1 MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY
61 VLRLNRVNDA QEYRRGGLGS LFYLTLDVLE TDCHVLRKKA WQDCGMRIFF ESVYGQCKAI
121 FYMNNPSRVL YLAAYNCTLR PVSKKKIYMT CPDCPSSIPT DSSNHQVLEA ATESLAKYNN
181 ENTSKQYSLF KVTRASSQWV VGPSYFVEYL IKESPCTKSQ ASSCSLQSSD SVPVGLCKGS
241 LTRTHWEKFV SVTCDFFESQ APATGSENSA VNQKPTNLPK VEESQQKNTP PTDSPSKAGP
301 RGSVQYLPDL DDKNSQEKGP QEAFPVHLDL TTNPQGETLD ISFLFLEPME EKLVVLPFPK
361 EKARTAECPG PAQNASPLVL PPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FETUB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 219 nTPM
Expression across tissuesHPA
Tissue
- liver: 219 nTPM
- esophagus: 8.2 nTPM
- pancreas: 6.1 nTPM
- tonsil: 5.5 nTPM
- skin: 2.5 nTPM
- vagina: 2.3 nTPM
Single-cell type
- esophageal apical cells: 70 nCPM
- hepatocytes: 56 nCPM
- early spermatids: 9.1 nCPM
- late spermatids: 8.3 nCPM
- kupffer cells: 5.1 nCPM
- suprabasal keratinocytes: 3.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- white matter: 0.4 nTPM
- amygdala: 0.2 nTPM
- medulla oblongata: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about FETUB.
Disease | ImmuneIEDB
Conditions an epitope on FETUB was assayed in.
- Lyme disease T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.37
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FETUB as an antibody target. Whether an autoantibody or antibody against FETUB could matter depends on whether native FETUB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FETUB is annotated as secreted, so native FETUB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label FETUB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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