Seroatlas · Human Serome Atlas

FDXACB1

Ferredoxin-fold anticodon-binding domain-containing protein 1

Also known as: FDXA1_HUMAN, hCG_2033039, LOC91893

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRP7
Gene
FDXACB1
Ensembl
ENSG00000255561
Chromosome
11
Canonical length
624 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

624 residues, UniProt reviewed canonical sequence.

>Q9BRP7|FDXACB1
     1  MAPRRLLLVG EGNFSFAAAL SETLDQSTQL TATCLQRPAE LARDPLAWEN LQCLRERGID
    61  VRFGVDCTQL ADVFELHERE FDQIYFIFPH CGRKAGVAKN RELLAKFFQS CADVLAEEGE
   121  VHVALCRGQG GTPADKPQRE WHNSWQVVAM AALGGLILSD VYPFSCKAVA GYKCTGYRSQ
   181  DKSFHVEGAL NHIFTRSLPF EGSQPRIFRI KLGNQWFSFP EPEALVGKLN RGFLEAPSCH
   241  PIKTINEKLI AELGKVFPLK RLKCSYPLLP QEGTSVLPFW NCDFLSAAFW ISLHEDNSNS
   301  ESLTGGTSQD VEDFLVSFSE LSLLKNPGRD GKEEACEGTC GQAKICLRPS LLVHVQDVIE
   361  VPDFLSGSLH ILSGPVFQKC HILPFTMPAF HETLFILGVN QNLKDGCLQS LLDHLKGILD
   421  SLLTQTLPES SKLSSLVKFV LQSNGKDYMI RVKTHNFSPD CTEDLIIGSV ITSATSVIHK
   481  DQCFVFVSMN LDLLAMLVWC ISDWRMLWTF DNRFLKNFVP GKIEPFKSHS LYPPCYVHDV
   541  SFWIDQKKGF DELEFHTVAR AVSQDTIISI QFLSRFQHPK TQQVSLCYRL TYQTCDKALT
   601  QQQVASMQSQ FRKEIQQHLY VIPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FDXACB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
3 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 3 nTPM
  • lymph node: 2.9 nTPM
  • testis: 2.9 nTPM
  • skin: 2.5 nTPM
  • epididymis: 2.2 nTPM
  • spleen: 2.2 nTPM

Single-cell type

  • cardiomyocytes: 13 nCPM
  • epicardial cells: 4.5 nCPM
  • early spermatids: 1.9 nCPM
  • adipocytes: 1.7 nCPM
  • mucous neck cells: 0.4 nCPM
  • other brain neurons: 0.4 nCPM

Immune cell

  • naive CD8 T-cell: 7.5 nTPM
  • naive CD4 T-cell: 6.5 nTPM
  • MAIT T-cell: 6.4 nTPM
  • gdT-cell: 4.9 nTPM
  • NK-cell: 4.8 nTPM
  • memory B-cell: 4.6 nTPM

Brain region

  • hypothalamus: 2.8 nTPM
  • basal ganglia: 2.4 nTPM
  • spinal cord: 2.4 nTPM
  • white matter: 2.4 nTPM
  • hippocampal formation: 2.3 nTPM
  • medulla oblongata: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FDXACB1 as an antibody target. Whether an autoantibody or antibody against FDXACB1 could matter depends on whether native FDXACB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FDXACB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FDXACB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FDXACB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...