FDCSP
Follicular dendritic cell secreted peptide
Also known as: C4orf7, FDC-SP, FDSCP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NFU4
- Gene
- FDCSP
- Ensembl
- ENSG00000181617
- Chromosome
- 4
- Canonical length
- 85 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
Canonical amino-acid sequenceUniProt
85 residues, UniProt reviewed canonical sequence.
>Q8NFU4|FDCSP
1 MKKVLLLITA ILAVAVGFPV SQDQEREKRS ISDSDELASG FFVFPYPYPF RPLPPIPFPR
61 FPWFRRNFPI PIPESAPTTP LPSEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FDCSP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 7,470 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 7,470 nTPM
- tonsil: 3,043 nTPM
- lymph node: 979 nTPM
- appendix: 295 nTPM
- breast: 170 nTPM
- small intestine: 54 nTPM
Single-cell type
- salivary acinar cells: 12,135 nCPM
- submucosal glandular cells: 2,794 nCPM
- lacrimal acinar cells: 1,256 nCPM
- salivary myoepithelial cells: 610 nCPM
- breast secretory cells: 259 nCPM
- salivary basal cells: 239 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 1.2 nTPM
- thalamus: 0.6 nTPM
- choroid plexus: 0.5 nTPM
- hypothalamus: 0.3 nTPM
- medulla oblongata: 0.2 nTPM
- pons: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.4
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -0.09
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Follicular dendritic cell secreted peptide
- Follicular dendritic cell secreted peptide
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FDCSP as an antibody target. Whether an autoantibody or antibody against FDCSP could matter depends on whether native FDCSP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FDCSP is annotated as secreted, so native FDCSP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Source-annotated serology context
The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.
- This protein specifically binds to activated B cells, and functions as a regulator of antibody responses.
Loading the interactive Seroatlas protein explorer...