Seroatlas · Human Serome Atlas

FCRLA

Fc receptor-like A

Also known as: FCRL, FCRLA_HUMAN, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRLM1, FCRLX, FREB, MGC4595

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L513
Gene: FCRLA
Ensembl: ENSG00000132185
Chromosome: 1
Canonical length: 359 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q7L513|FCRLA
     1  MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF
    61  QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG
   121  PPGPNREFSI TVVQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA
   181  EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC
   241  EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS
   301  SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK PGTTKATAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCRLA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

tonsil: 92 nTPM
lymph node: 64 nTPM
spleen: 36 nTPM
appendix: 22 nTPM
small intestine: 18 nTPM
thymus: 7.2 nTPM

Single-cell type

b-cells: 68 nCPM
melanocytes: 27 nCPM
plasma cells: 16 nCPM
pdcs: 6.8 nCPM
foveolar cells: 2.9 nCPM
gastric chief cells: 2.2 nCPM

Immune cell

memory B-cell: 369 nTPM
naive B-cell: 343 nTPM
plasmacytoid DC: 39 nTPM
total PBMC: 17 nTPM
gdT-cell: 0.8 nTPM
neutrophil: 0.6 nTPM

Brain region

cerebellum: 5.1 nTPM
cerebral cortex: 4.2 nTPM
amygdala: 3.8 nTPM
thalamus: 3.8 nTPM
medulla oblongata: 3.5 nTPM
midbrain: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCRLA as an antibody target. Whether an autoantibody or antibody against FCRLA could matter depends on whether native FCRLA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCRLA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies.

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