Seroatlas · Human Serome Atlas

FCRL1

Fc receptor-like protein 1

Also known as: CD307a, FCRH1, FCRL1_HUMAN, IFGP1, IRTA5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LA6
Gene
FCRL1
Ensembl
ENSG00000163534
Chromosome
1
Canonical length
429 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q96LA6|FCRL1
     1  MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA
    61  LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP
   121  GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ
   181  YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY
   241  WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA
   301  RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP
   361  TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAAETLG THMEDKVSLD IYSRLRKANI
   421  TDVDYEDAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCRL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 26 nTPM
  • tonsil: 21 nTPM
  • spleen: 17 nTPM
  • appendix: 9.5 nTPM
  • small intestine: 7.9 nTPM
  • bone marrow: 7.6 nTPM

Single-cell type

  • b-cells: 543 nCPM
  • neutrophils: 119 nCPM
  • neutrophil progenitors: 72 nCPM
  • medullary thymic epithelial cells: 9.6 nCPM
  • plasma cells: 9.6 nCPM
  • conjunctival goblet cells: 8.7 nCPM

Immune cell

  • naive B-cell: 68 nTPM
  • memory B-cell: 39 nTPM
  • total PBMC: 2.1 nTPM
  • neutrophil: 1.1 nTPM
  • intermediate monocyte: 0.5 nTPM
  • non-classical monocyte: 0.5 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • choroid plexus: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCRL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCRL1 as an antibody target. Whether an autoantibody or antibody against FCRL1 could matter depends on whether native FCRL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCRL1 is annotated at the cell surface, where native FCRL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCRL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FCRL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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