Seroatlas · Human Serome Atlas

FCGR2C

Low affinity immunoglobulin gamma Fc region receptor II-c

Also known as: FCG2C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P31995
Gene: FCGR2C
Canonical length: 323 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for FCGR2C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P31995|FCGR2C
     1  MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN
    61  VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL
   121  SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN
   181  FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA
   241  VVALIYCRKK RISANSTDPV KAAQFEPPGR QMIAIRKRQP EETNNDYETA DGGYMTLNPR
   301  APTDDDKNIY LTLPPNDHVN SNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCGR2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

placenta: 27 nTPM
tonsil: 2.4 nTPM
smooth muscle: 2.3 nTPM
adipose tissue: 1.8 nTPM
appendix: 1.7 nTPM
lung: 1.4 nTPM

Single-cell type

macrophages: 29 nCPM
cdc: 23 nCPM
monocytes: 16 nCPM
microglia: 13 nCPM
b-cells: 3.9 nCPM
lymphatic endothelial cells: 3.7 nCPM

Immune cell

neutrophil: 7.4 nTPM
myeloid DC: 4.2 nTPM
eosinophil: 3.5 nTPM
non-classical monocyte: 3 nTPM
classical monocyte: 2.7 nTPM
intermediate monocyte: 2.7 nTPM

Brain region

choroid plexus: 8.1 nTPM
white matter: 5.4 nTPM
medulla oblongata: 4.5 nTPM
thalamus: 3.8 nTPM
spinal cord: 3.7 nTPM
pons: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.2

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCGR2C as an antibody target. Whether an autoantibody or antibody against FCGR2C could matter depends on whether native FCGR2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCGR2C is annotated at the cell surface, where native FCGR2C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCGR2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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