Seroatlas · Human Serome Atlas

FCGR1BP

Putative high affinity immunoglobulin gamma Fc receptor IB

Also known as: FCGRB_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92637
Gene: FCGR1BP
Canonical length: 280 aa

OverviewNCBI Gene

No narrative summary is available for FCGR1BP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q92637|FCGR1BP
     1  MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG
    61  TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFMEGEPL
   121  ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG
   181  ISQYTVKGLQ LPTPVWFHVL FYLAVGIMFL VNTVLWVTIR KELKRKKKWN LEISLDSGHE
   241  KKVISSLQED RHLEEELKCQ EQKEEQLQEG VHRKEPQGAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCGR1BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCGR1BP as an antibody target. Whether an autoantibody or antibody against FCGR1BP could matter depends on whether native FCGR1BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCGR1BP is annotated at the cell surface, where native FCGR1BP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCGR1BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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