Seroatlas · Human Serome Atlas

FCF1

rRNA-processing protein FCF1 homolog

Also known as: Bka, C14orf111, CGI-35, FCF1_HUMAN, UTP24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y324
Gene: FCF1
Ensembl: ENSG00000119616
Chromosome: 14
Canonical length: 198 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9Y324|FCF1
     1  MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN
    61  TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKYRVA
   121  LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYIS
   181  NHRYNIERMP DDYGAPRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 41 nTPM
tonsil: 39 nTPM
fallopian tube: 36 nTPM
ovary: 34 nTPM
breast: 33 nTPM
lymph node: 32 nTPM

Single-cell type

hepatocytes: 110 nCPM
respiratory ciliated cells: 56 nCPM
hepatic stellate cells: 52 nCPM
fallopian tube ciliated cells: 50 nCPM
epididymal efferent duct ciliated cells: 48 nCPM
erythrocyte progenitors: 47 nCPM

Immune cell

plasmacytoid DC: 31 nTPM
memory B-cell: 24 nTPM
naive B-cell: 21 nTPM
MAIT T-cell: 21 nTPM
eosinophil: 21 nTPM
naive CD8 T-cell: 21 nTPM

Brain region

white matter: 38 nTPM
midbrain: 29 nTPM
medulla oblongata: 29 nTPM
cerebellum: 29 nTPM
hypothalamus: 29 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.02
gnomAD missense Z: 0.89
DepMap mean gene effect: -1.4
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

PIN domain
Fcf1/UTP23
PIN-like domain superfamily
Fcf1
rRNA-processing protein Fcf1, PIN domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCF1 as an antibody target. Whether an autoantibody or antibody against FCF1 could matter depends on whether native FCF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FCF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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