Seroatlas · Human Serome Atlas

FBXW7-AS1

Dual endothelin-1/VEGF signal peptide receptor

Also known as: DESPR_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B0L3A2
Gene: FBXW7-AS1
Canonical length: 85 aa

OverviewNCBI Gene

No narrative summary is available for FBXW7-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>B0L3A2|FBXW7-AS1
     1  MTMFKGSNEM KSRWNWGSIT CIICFTCVGS QLSMSSSKAS NFSGPLQLYQ RELEIFIVLT
    61  DVPNYRLIKE NSHLHTTIVD QGRTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW7-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW7-AS1 as an antibody target. Whether an autoantibody or antibody against FBXW7-AS1 could matter depends on whether native FBXW7-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW7-AS1 is annotated at the cell surface, where native FBXW7-AS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FBXW7-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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