Seroatlas · Human Serome Atlas

FANCD2OS

FANCD2 opposite strand protein

Also known as: C3orf24, FACOS_HUMAN, MGC40179

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PS1
Gene: FANCD2OS
Ensembl: ENSG00000163705
Chromosome: 3
Canonical length: 177 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q96PS1|FANCD2OS
     1  MAGYQLWSPW TPLDESFQWL RHTTPTPSSK HPFKASPCFP HTPSDLEVQL CFQEVTLVLD
    61  SPFLESGVSP KLPCHTSELR TMNNKGLVRK PQPIRLSGVD SVFGRVITAQ PPKWTGTFRV
   121  SDKSAFCKII SREHQWPIGL KEPQIQMTVT MCKQMLRSIL LLYATYKKCT FALQHSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FANCD2OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
bone marrow: 0.9 nTPM
skin: 0.4 nTPM
gallbladder: 0.2 nTPM
lymph node: 0.1 nTPM
spleen: 0.1 nTPM

Single-cell type

late spermatids: 1,079 nCPM
early spermatids: 664 nCPM
late primary spermatocytes: 222 nCPM
early primary spermatocytes: 67 nCPM
differentiating spermatogonia: 41 nCPM
undifferentiated spermatogonia: 15 nCPM

Immune cell

neutrophil: 5.3 nTPM
non-classical monocyte: 1 nTPM
naive B-cell: 0.8 nTPM
basophil: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM

Brain region

cerebellum: 5 nTPM
pons: 1.8 nTPM
amygdala: 1.7 nTPM
cerebral cortex: 1.7 nTPM
white matter: 1.7 nTPM
hippocampal formation: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.02
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of testosterone biosynthetic process

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

FANCD2 opposite strand protein
FANCD2 opposite strand protein

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FANCD2OS as an antibody target. Whether an autoantibody or antibody against FANCD2OS could matter depends on whether native FANCD2OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FANCD2OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FANCD2OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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