Seroatlas · Human Serome Atlas

FAM98C

Protein FAM98C

Also known as: FA98C_HUMAN, FLJ44669

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RN3
Gene: FAM98C
Ensembl: ENSG00000130244
Chromosome: 19
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q17RN3|FAM98C
     1  MEAVKAEAWE GAAVAQDLLA LGYGGVPGAA SRGASCPDFR GLCVRLAAEL ATLGALEQQR
    61  EAGAEVLSAG DGPGAEEDFL RQLGSLLREL HCPDRALCGG DGAAALREPG AGLRLLRFLC
   121  SELQATRLLC LRSLLDPSPR PPLGEGVVEG AGMVQELDLT LQALGLPRPA PGTPASQLLQ
   181  ELHAKISELQ PSLPPGSLQP LLSCSLDAPR WEALESLSQS LRDQYRCRRC LLLKRLDLTT
   241  SAFHWSDRAE AQGEAMRAVL IPIREVLTPE SDISIAHVLA ARADLSCLVP ATSVAVRRGT
   301  CCAINKVLMG NVPDRGGRPN ELEPPMPTWR SRREDGGPQC WGRKKKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM98C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 26 nTPM
amygdala: 25 nTPM
skin: 23 nTPM
basal ganglia: 23 nTPM
hippocampal formation: 22 nTPM
cerebellum: 21 nTPM

Single-cell type

enterocytes: 90 nCPM
esophageal apical cells: 63 nCPM
esophageal suprabasal cells: 51 nCPM
early primary spermatocytes: 50 nCPM
esophageal basal cells: 44 nCPM
colonocytes: 44 nCPM

Immune cell

eosinophil: 11 nTPM
naive B-cell: 6.3 nTPM
memory CD4 T-cell: 4 nTPM
T-reg: 3.7 nTPM
memory CD8 T-cell: 3.3 nTPM
naive CD4 T-cell: 3.2 nTPM

Brain region

medulla oblongata: 31 nTPM
cerebral cortex: 23 nTPM
white matter: 21 nTPM
amygdala: 21 nTPM
hypothalamus: 21 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

tRNA-splicing ligase complex

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FAM98C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDX1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM98C as an antibody target. Whether an autoantibody or antibody against FAM98C could matter depends on whether native FAM98C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM98C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM98C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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