Seroatlas · Human Serome Atlas

FAM90A8

Protein FAM90A8

Also known as: F90A8_HUMAN, FAM90A8P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJQ4
Gene
FAM90A8
Ensembl
ENSG00000285937
Chromosome
8
Canonical length
464 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

FAM90A8 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>A6NJQ4|FAM90A8
     1  MMARRDPKSW AKRLVRAQTL QKQRRAPVGP SAPPPDEEDP RLKCKNCGAF GHTARSTRCP
    61  MKCWKAALVP ATLGKKEGKE NLKPWKPRGE ANPGPLNKDK GEKEERPRQQ DPQRKALLHM
   121  FSGKPPEKPL PNGKGSTESS DHLRVASGPM PVHTTSKRPR VDPVLADRSA AEMSGRGSVL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PQPAVRHQGR EPLLVVKPTH SRPEGGCREV
   241  PQAASKTHGL LQAARPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRPAQAPIQA
   301  CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPSTSPQMGR RTPAQVPSID
   361  RQPPHSTPCL PTAQACTMSH HSAASHDGAQ PLRVLFRRLE NGRWSSSLLA APSFHSPEKP
   421  GAFLAQSPHV SEKSEAPCVR VPPSVLYEDL QVSSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A8 as an antibody target. Whether an autoantibody or antibody against FAM90A8 could matter depends on whether native FAM90A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM90A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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