Seroatlas · Human Serome Atlas

FAM90A3

Protein FAM90A3

Also known as: F90A3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A8V8TPE2
Gene
FAM90A3
Canonical length
464 aa

OverviewNCBI Gene

No narrative summary is available for FAM90A3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>A0A8V8TPE2|FAM90A3
     1  MMARRDPTSW AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCGAF GHTARSTRCP
    61  MKCWKAALVP ATLGKKEGKE NLKPWKPRVE ANPGPLNKDK GEKEERPRQQ DPQRKALLHM
   121  FSGKPPEKPL PNGKGSTEPS DYLRVASGPM PVHTTSKRPR VDPVLADGSA TEMSDRGSVL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PQPAVRHQGR EPLLVVKPTH SSPEGGCREV
   241  PQAASKTHGL LQAARPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRPAQAPIQA
   301  CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPSTSPQMGR RTPAQVPSVE
   361  RQPPHSRPCL PTAQACTMSH HSAASHDGAQ PLRVLFRRLE NGRWSSSLLA APSFHSPEKP
   421  GAFLAQSPHV SEKSEAPCVR VPPSVLYEDL QVSSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A3 as an antibody target. Whether an autoantibody or antibody against FAM90A3 could matter depends on whether native FAM90A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM90A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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