Seroatlas · Human Serome Atlas

FAM90A26

Protein FAM90A26

Also known as: F90AP_HUMAN, FAM90A26P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
D6RGX4
Gene
FAM90A26
Ensembl
ENSG00000229924
Chromosome
4
Canonical length
464 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for FAM90A26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>D6RGX4|FAM90A26
     1  MMACRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCGAF GHMARSTRCP
    61  MKCWKAALVP PTLGKKEGKE NLKPWKPQVE ANPGPLNKDK GEKEERPRQQ DPQRKALLHI
   121  FSGKPPEKPL PNRKGSTESS VYLRVASGPM PVHTTSKRPR VDPVLADRSA TEMSDRGSAL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PQPAVRHQGP EPLLVVKPTH SSPEGGCREV
   241  PQAASKTHGL LQAISPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRPAQAPIQA
   301  CLNFPKKPRL GPFQIPESAI QGGELGAPEY LQPPPATTEL GPSTSPQMGR RTPAQVSSVD
   361  RQPPHSRPCL PTAQACTMSH HPATSHDGAQ PLRVLFRRLE NGRWSSSLLA APSFHSPEKP
   421  GAFLAQSPHV SEKSEVPRVR VPPNVLYEDL QVSSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.2 nTPM
  • adrenal gland: 0.1 nTPM
  • retina: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • epididymal principal cells: 12 nCPM
  • epicardial cells: 2.3 nCPM
  • epididymal basal cells: 0.6 nCPM
  • myosatellite cells: 0.5 nCPM
  • astrocytes: 0.2 nCPM
  • bergmann glia: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • hypothalamus: 1.3 nTPM
  • white matter: 1.3 nTPM
  • hippocampal formation: 1.2 nTPM
  • pons: 1.2 nTPM
  • amygdala: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0.29
gnomAD missense Z
-0.81

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A26 as an antibody target. Whether an autoantibody or antibody against FAM90A26 could matter depends on whether native FAM90A26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM90A26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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