Seroatlas · Human Serome Atlas

FAM90A20

Protein FAM90A20

Also known as: F90AK_HUMAN, FAM90A20P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NIJ5
Gene
FAM90A20
Ensembl
ENSG00000233295
Chromosome
8
Canonical length
464 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

FAM90A20 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>A6NIJ5|FAM90A20
     1  MMARRDPTSW AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCGAF GHTARSTRCP
    61  MKCWKAALVP ATLGKKEGKE NLKPWKPGVE ANPGPLNKDK GEKEERPRQQ DPQRKALLHM
   121  FSGKPPEKPL PNGKGSTESS DYLRVARGPM PVHTTCKRPR MDPVLSGRSA TEMSGRGSVL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PRPAVRHQVH ETLLVVEPTH SSPEGSCREV
   241  PQAASKTHGL LQAVRTQAQD KRPAVTSQPC PSAATHSLGL GSNLSFGSGA KRPAQAPIQA
   301  CLNFPKKPRL GPFQIPESTI QGGELGAPEN LQPPPAATEL GPSRSPQMGR RTPAQVPSVE
   361  RQPPHRRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE NGRWSSSLLA APSFHSPEKP
   421  GAFLAQSPHV SEKSEAPCVR VPPSVLYEDL QVSSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.2 nTPM
  • salivary gland: 0.2 nTPM
  • skin: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • cardiomyocytes: 0.2 nCPM
  • microglia: 0.1 nCPM
  • oligodendrocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 9.7 nTPM
  • white matter: 8.4 nTPM
  • basal ganglia: 7.8 nTPM
  • pons: 7.3 nTPM
  • cerebral cortex: 7 nTPM
  • midbrain: 6.9 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A20 as an antibody target. Whether an autoantibody or antibody against FAM90A20 could matter depends on whether native FAM90A20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM90A20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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