Seroatlas · Human Serome Atlas

FAM90A12

Protein FAM90A12

Also known as: F90AC_HUMAN, FAM90A12P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MX19
Gene
FAM90A12
Ensembl
ENSG00000254229
Chromosome
8
Canonical length
464 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

FAM90A12 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>A8MX19|FAM90A12
     1  MMARRDPKSW AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCGAF GHTARSTRCP
    61  MKCWKAALVP ATLGKKEGKE NLKPWKPRAE ANPGPLNKDK GEKEERPRQQ DPQRKALLHM
   121  FSGKPPEKPL PNGKGSTESS DYLRVASGPM PVHTSSKRPR LDPILADRSA TAMSGRGSVL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADM PQPAVRHEGR EPLLVVKPTH SRPEGGCREV
   241  PQAASKTHGL PQAARPQAQD KRPAVTSLPC PPAATHSLGL GSNLSFGPGA KRPAQAPIQA
   301  CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPSTSPQMGR RTPAQVPSVD
   361  RQPPHSRPCL PTAQACTMSH HSAASHDGAQ PLRVLFRRLE NGRWSSSLLA APSFHSPEKP
   421  GAFLAQSPHV SEKSEAPCVR VPPSVLYEDL QVSSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.2 nTPM
  • epididymis: 0.2 nTPM
  • skin: 0.2 nTPM
  • choroid plexus: 0.1 nTPM
  • retina: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM

Single-cell type

  • gonadotrophs: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 7.5 nTPM
  • basal ganglia: 7 nTPM
  • amygdala: 6.7 nTPM
  • white matter: 6.1 nTPM
  • hippocampal formation: 5.9 nTPM
  • hypothalamus: 5.3 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A12 as an antibody target. Whether an autoantibody or antibody against FAM90A12 could matter depends on whether native FAM90A12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM90A12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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