Seroatlas · Human Serome Atlas

FAM89B

Leucine repeat adapter protein 25

Also known as: LRA25_HUMAN, LRAP25, MTVR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5H3
Gene: FAM89B
Ensembl: ENSG00000176973
Chromosome: 11
Canonical length: 189 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transcription corepressor binding activity. Predicted to be involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Predicted to be located in cell projection. Predicted to be active in cytoplasm and lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q8N5H3|FAM89B
     1  MNGLPSAEAP GGAGCALAGL PPLPRGLSGL LNASGGSWRE LERVYSQRSR IHDELSRAAR
    61  APDGPRHAAG AANAGPAAGP RRPVNLDSAL AALRKEMVGL RQLDMSLLCQ LWGLYESIQD
   121  YKHLCQDLSF CQDLSSSLHS DSSYPPDAGL SDDEEPPDAS LPPDPPPLTV PQTHNARDQW
   181  LQDAFHISL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM89B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 128 nTPM
tongue: 89 nTPM
blood vessel: 75 nTPM
pancreas: 74 nTPM
colon: 70 nTPM
cerebral cortex: 66 nTPM

Single-cell type

esophageal apical cells: 117 nCPM
megakaryocytes: 99 nCPM
platelets: 90 nCPM
breast secretory cells: 86 nCPM
plasma cells: 74 nCPM
smooth muscle cells: 63 nCPM

Immune cell

non-classical monocyte: 14 nTPM
eosinophil: 12 nTPM
intermediate monocyte: 11 nTPM
T-reg: 10 nTPM
neutrophil: 8.5 nTPM
basophil: 7.9 nTPM

Brain region

cerebral cortex: 75 nTPM
hippocampal formation: 64 nTPM
amygdala: 60 nTPM
white matter: 54 nTPM
basal ganglia: 52 nTPM
thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0.05
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription corepressor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM89B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM89B as an antibody target. Whether an autoantibody or antibody against FAM89B could matter depends on whether native FAM89B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM89B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM89B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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