Seroatlas · Human Serome Atlas

FAM89A

Protein FAM89A

Also known as: C1orf153, FA89A_HUMAN, MGC15887

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GI7
Gene
FAM89A
Ensembl
ENSG00000182118
Chromosome
1
Canonical length
184 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

No narrative summary is available for FAM89A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q96GI7|FAM89A
     1  MSGARAAPGA AGNGAVRGLR VDGLPPLPKS LSGLLHSASG GGASGGWRHL ERLYAQKSRI
    61  QDELSRGGPG GGGARAAALP AKPPNLDAAL ALLRKEMVGL RQLDMSLLCQ LYSLYESIQE
   121  YKGACQAASS PDCTYALENG FFDEEEEYFQ EQNSLHDRRD RGPPRDLSLP VSSLSSSDWI
   181  LESI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM89A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 64 nTPM
  • adipose tissue: 56 nTPM
  • breast: 36 nTPM
  • midbrain: 30 nTPM
  • skin: 29 nTPM
  • choroid plexus: 25 nTPM

Single-cell type

  • extravillous trophoblasts: 405 nCPM
  • syncytiotrophoblasts: 294 nCPM
  • cytotrophoblasts: 243 nCPM
  • podocytes: 154 nCPM
  • migrating cytotrophoblasts: 154 nCPM
  • rod photoreceptor cells: 90 nCPM

Immune cell

  • basophil: 1.4 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • memory B-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM

Brain region

  • thalamus: 34 nTPM
  • hypothalamus: 30 nTPM
  • medulla oblongata: 29 nTPM
  • midbrain: 27 nTPM
  • spinal cord: 26 nTPM
  • choroid plexus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0.26
gnomAD missense Z
0.24
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM89A as an antibody target. Whether an autoantibody or antibody against FAM89A could matter depends on whether native FAM89A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM89A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM89A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM89A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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