Seroatlas · Human Serome Atlas

FAM87A

Protein FAM87A

Also known as: FA87A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7U9
Gene
FAM87A
Canonical length
286 aa

OverviewNCBI Gene

No narrative summary is available for FAM87A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>P0C7U9|FAM87A
     1  MTGTLERENW ISGGKSLVLR KQHPGPLRPW RKRAAQLGGG CGWRTAVAPA KFCLWYVVPS
    61  WLWEPPGYLH SSLFLSILFQ VTLLETALQS RPNLSLPLVR CGWACTQAMS TRSNCGSRSF
   121  LWAQTQADAA SGLPRSRLGF LGLGGCGLIV KHGMTLRNWA SFFVVFQAWS LMILQVLGDM
   181  LNIYYAYIQA TLTLKVDVAP RLFFPEGGAL KEHFSSMDSF QLREAGGTRI PRPALIYGRA
   241  VVTRTVTKAQ SLKSALAWAA LGCKHPVLST LCEESQQGAW SEFRRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM87A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.49

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM87A as an antibody target. Whether an autoantibody or antibody against FAM87A could matter depends on whether native FAM87A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM87A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM87A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM87A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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