Seroatlas · Human Serome Atlas

FAM86B1

Putative protein N-methyltransferase FAM86B1

Also known as: F86B1_HUMAN, MGC16279

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7N1
Gene: FAM86B1
Ensembl: ENSG00000186523
Chromosome: 8
Canonical length: 330 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q8N7N1|FAM86B1
     1  MAPEENAGTE LLLQGFERRF LAVRTLRSFP WQSLEAKLRD SSDSELLRDI LQKTVRHPVC
    61  VKHPPSVKYA WCFLSELIKK HEAVHTEPLD KLYEVLTETL MAKESTQGHR SYLLSSGGSV
   121  TLSKSTAIIS HGTTGLVTWD AALYLAEWAI ENPAAFINRT VLELGSGAGL TGLAICKMCR
   181  PRAYIFSDPH SRVLEQLRGN VLLNGLSLEA DITGNLDSPR VTVAQLDWDV AMVHQLSAFQ
   241  PDVVIAADVL YCPEAIVSLV GVLQRLAACR EHKRAPEVYV AFTVRNPETC QLFTTELGRD
   301  GIRWEAEAHH DQKLFPYGEH LEMAMLNLTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM86B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 7.3 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 7.3 nTPM
pituitary gland: 6.9 nTPM
cerebellum: 6.2 nTPM
cerebral cortex: 5.5 nTPM
hypothalamus: 4.5 nTPM
ovary: 4.4 nTPM

Single-cell type

ependymal cells: 5.2 nCPM
proximal tubule cells: 3.8 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM
choroid plexus epithelial cells: 2.6 nCPM
renal collecting duct principal cells: 2.5 nCPM
medullary thymic epithelial cells: 2.4 nCPM

Immune cell

neutrophil: 1.3 nTPM
basophil: 1.1 nTPM
eosinophil: 1.1 nTPM
memory B-cell: 0.2 nTPM
T-reg: 0.2 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

cerebral cortex: 50 nTPM
basal ganglia: 44 nTPM
hippocampal formation: 42 nTPM
amygdala: 39 nTPM
white matter: 37 nTPM
hypothalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -2.17

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM86B1 as an antibody target. Whether an autoantibody or antibody against FAM86B1 could matter depends on whether native FAM86B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM86B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM86B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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