Seroatlas · Human Serome Atlas

FAM81B

Protein FAM81B

Also known as: FA81B_HUMAN, FLJ25333

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LP2
Gene: FAM81B
Ensembl: ENSG00000153347
Chromosome: 5
Canonical length: 452 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q96LP2|FAM81B
     1  MQLQFLGTLA SSEKRKKSQR LFFKNIKSTK NKAGKASIMS SDTNVNKSAS PTATAEEQPV
    61  EPDGPLPGSD NNQEKKVRLS PAKMSTKNST DLVEYVDKSH AFLPIIPNTQ RGQLEDRLNN
   121  QARTIAFLLE QAFRIKEDIS ACLQGTHGFR KEESLARKLL ESHIQTITSI VKKLSQNIEI
   181  LEDQIRARDQ AATGTNFAVH EINIKHLQGV GDLRGRVARC DSSIVKLSGD IHLFRQEHRQ
   241  IEKAIQEFVP ALETLSKNLD MKVMQLLGKI ETASSEQTSN LKMVQGDYRH EMNLLEFKFH
   301  SLSSNLYEEV ENNKKWTENQ FLKYRKDHLG HINECLKVLQ EKLEKSENKM EEKLLQLSSK
   361  VENFINTQKQ ETQLSKVKHM ENKLSKKMEQ MEKQIWGELE TMQNEYQSGF KSIHDSLSSL
   421  QQIQKTKMDL EKYKVQKDLK KLQRKIVELQ EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM81B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

testis: 79 nTPM
choroid plexus: 59 nTPM
fallopian tube: 45 nTPM
heart muscle: 7.2 nTPM
hypothalamus: 6.4 nTPM
hippocampal formation: 5.3 nTPM

Single-cell type

late spermatids: 2,644 nCPM
early spermatids: 955 nCPM
fallopian tube ciliated cells: 458 nCPM
respiratory ciliated cells: 396 nCPM
epididymal efferent duct ciliated cells: 383 nCPM
late primary spermatocytes: 323 nCPM

Immune cell

basophil: 6.7 nTPM
total PBMC: 0.3 nTPM
myeloid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 35 nTPM
midbrain: 12 nTPM
medulla oblongata: 9.4 nTPM
white matter: 9.2 nTPM
spinal cord: 8.1 nTPM
cerebellum: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Protein FAM81

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM81B as an antibody target. Whether an autoantibody or antibody against FAM81B could matter depends on whether native FAM81B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM81B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM81B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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