Seroatlas · Human Serome Atlas

FAM78B

Protein FAM78B

Also known as: FA78B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VT40
Gene
FAM78B
Ensembl
ENSG00000188859
Chromosome
1
Canonical length
261 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

No narrative summary is available for FAM78B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q5VT40|FAM78B
     1  MGCIQSITCK ARIRRENIVV YDVCATIDQC PTRIEETSPI VLRYKTPYFK ASARVVMPPI
    61  PRHETWVVGW IQACNQMEFF NTYSDLGMSS WELPDLREGR VKAISDSDGV SYPWYGNTTE
   121  TVTLVGPTNK ISRFSVSMND NFYPSVTWAV PVSDSNVPLL TRIKRDQSFT TWLVAMNTTT
   181  KEKIILQTIK WRMRVDIEVD PLQLLGQRAR LVGRTQQEQP RILSRMEPIP PNALVKPNAN
   241  DAQVLMWRPK RGPPLVVIPP K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM78B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.8 nTPM
  • cervix: 0.7 nTPM
  • testis: 0.7 nTPM
  • liver: 0.6 nTPM
  • skeletal muscle: 0.6 nTPM
  • adipose tissue: 0.5 nTPM

Single-cell type

  • retinal horizontal cells: 615 nCPM
  • cone photoreceptor cells: 311 nCPM
  • sertoli cells: 97 nCPM
  • retinal bipolar cells: 81 nCPM
  • rod photoreceptor cells: 77 nCPM
  • brain inhibitory neurons: 65 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 9.4 nTPM
  • hippocampal formation: 5.8 nTPM
  • amygdala: 5.4 nTPM
  • basal ganglia: 5.2 nTPM
  • white matter: 4.8 nTPM
  • cerebellum: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.31
gnomAD missense Z
1.55
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM78B as an antibody target. Whether an autoantibody or antibody against FAM78B could matter depends on whether native FAM78B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM78B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM78B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM78B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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