FAM78A
Protein FAM78A
Also known as: C9orf59, FA78A_HUMAN, FLJ00024
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JUQ0
- Gene
- FAM78A
- Ensembl
- ENSG00000126882
- Chromosome
- 9
- Canonical length
- 283 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
No narrative summary is available for FAM78A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
283 residues, UniProt reviewed canonical sequence.
>Q5JUQ0|FAM78A
1 MPGFFCDCWP SLEIRALLYA MGCIQSIGGK ARVFREGITV IDVKASIDPV PTSIDESSSV
61 VLRYRTPHFR ASAQVVMPPI PKKETWVVGW IQACSHMEFY NQYGEQGMSS WELPDLQEGK
121 IQAISDSDGV NYPWYGNTTE TCTIVGPTKR DSKFIISMND NFYPSVTWAV PVSESNVAKL
181 TNIYRDQSFT TWLVATNTST NDMIILQTLH WRMQLSIEVN PNRPLGQRAR LREPIAQDQP
241 KILSKNEPIP PSALVKPNAN DAQVLMWRPK YGQPLVVIPP KHRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM78A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 59 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 59 nTPM
- testis: 30 nTPM
- heart muscle: 25 nTPM
- lymph node: 25 nTPM
- bone marrow: 22 nTPM
- thymus: 21 nTPM
Single-cell type
- late spermatids: 185 nCPM
- retinal bipolar cells: 117 nCPM
- early spermatids: 112 nCPM
- extravillous trophoblasts: 58 nCPM
- microglia: 53 nCPM
- hofbauer cells: 43 nCPM
Immune cell
- eosinophil: 18 nTPM
- naive B-cell: 16 nTPM
- memory B-cell: 15 nTPM
- intermediate monocyte: 13 nTPM
- naive CD4 T-cell: 11 nTPM
- memory CD8 T-cell: 10 nTPM
Brain region
- white matter: 16 nTPM
- cerebral cortex: 16 nTPM
- thalamus: 16 nTPM
- medulla oblongata: 15 nTPM
- basal ganglia: 15 nTPM
- hippocampal formation: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.7
- gnomAD pLI
- 0.37
- gnomAD missense Z
- 1.8
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM78A as an antibody target. Whether an autoantibody or antibody against FAM78A could matter depends on whether native FAM78A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM78A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM78A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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