Seroatlas · Human Serome Atlas

FAM76B

Protein FAM76B

Also known as: FA76B_HUMAN, MGC33371

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYJ3
Gene: FAM76B
Ensembl: ENSG00000077458
Chromosome: 11
Canonical length: 339 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in several processes, including mRNA stabilization; negative regulation of macrophage activation; and negative regulation of protein export from nucleus. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q5HYJ3|FAM76B
     1  MAASALYACT KCTQRYPFEE LSQGQQLCKE CRIAHPIVKC TYCRSEFQQE SKTNTICKKC
    61  AQNVKQFGTP KPCQYCNIIA AFIGTKCQRC TNSEKKYGPP QTCEQCKQQC AFDRKEEGRR
   121  KVDGKLLCWL CTLSYKRVLQ KTKEQRKSLG SSHSNSSSSS LTEKDQHHPK HHHHHHHHHH
   181  RHSSSHHKIS NLSPEEEQGL WKQSHKSSAT IQNETPKKKP KLESKPSNGD SSSINQSADS
   241  GGTDNFVLIS QLKEEVMSLK RLLQQRDQTI LEKDKKLTEL KADFQYQESN LRTKMNSMEK
   301  AHKETVEQLQ AKNRELLKQV AALSKGKKFD KSGSILTSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM76B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 37 nTPM
testis: 17 nTPM
tonsil: 17 nTPM
lymph node: 16 nTPM
thymus: 13 nTPM
appendix: 12 nTPM

Single-cell type

late spermatids: 665 nCPM
early spermatids: 320 nCPM
late primary spermatocytes: 118 nCPM
neutrophils: 67 nCPM
neutrophil progenitors: 63 nCPM
monocyte progenitors: 58 nCPM

Immune cell

neutrophil: 5.7 nTPM
T-reg: 5.3 nTPM
plasmacytoid DC: 4.8 nTPM
naive CD8 T-cell: 4.1 nTPM
eosinophil: 3.5 nTPM
memory CD8 T-cell: 3.4 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 11 nTPM
medulla oblongata: 8.6 nTPM
midbrain: 8.4 nTPM
thalamus: 8.2 nTPM
cerebral cortex: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.34
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

nuclear speck

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM76B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HNRNPA2B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM76B as an antibody target. Whether an autoantibody or antibody against FAM76B could matter depends on whether native FAM76B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM76B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM76B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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