Seroatlas · Human Serome Atlas

FAM76A

Protein FAM76A

Also known as: FA76A_HUMAN, MGC34648

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAV0
Gene: FAM76A
Ensembl: ENSG00000009780
Chromosome: 1
Canonical length: 307 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q8TAV0|FAM76A
     1  MAALYACTKC HQRFPFEALS QGQQLCKECR IAHPVVKCTY CRTEYQQESK TNTICKKCAQ
    61  NVQLYGTPKP CQYCNIIAAF IGNKCQRCTN SEKKYGPPYS CEQCKQQCAF DRKDDRKKVD
   121  GKLLCWLCTL SYKRVLQKTK EQRKHLSSSS RAGHQEKEQY SRLSGGGHYN SQKTLSTSSI
   181  QNEIPKKKSK FESITTNGDS FSPDLALDSP GTDHFVIIAQ LKEEVATLKK MLHQKDQMIL
   241  EKEKKITELK ADFQYQESQM RAKMNQMEKT HKEVTEQLQA KNRELLKQAA ALSKSKKSEK
   301  SGAITSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM76A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
adipose tissue: 20 nTPM
testis: 17 nTPM
thyroid gland: 15 nTPM
retina: 14 nTPM
bone marrow: 13 nTPM

Single-cell type

early spermatids: 168 nCPM
late spermatids: 151 nCPM
choroid plexus epithelial cells: 66 nCPM
rod photoreceptor cells: 65 nCPM
differentiating spermatogonia: 62 nCPM
early primary spermatocytes: 61 nCPM

Immune cell

MAIT T-cell: 11 nTPM
plasmacytoid DC: 11 nTPM
naive CD8 T-cell: 11 nTPM
eosinophil: 11 nTPM
memory CD4 T-cell: 11 nTPM
gdT-cell: 10 nTPM

Brain region

white matter: 37 nTPM
choroid plexus: 36 nTPM
cerebellum: 32 nTPM
medulla oblongata: 30 nTPM
hypothalamus: 30 nTPM
cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.82
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM76A as an antibody target. Whether an autoantibody or antibody against FAM76A could matter depends on whether native FAM76A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM76A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM76A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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