Seroatlas · Human Serome Atlas

FAM72D

Protein FAM72D

Also known as: FA72D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6L9T8
Gene
FAM72D
Ensembl
ENSG00000215784
Chromosome
1
Canonical length
149 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q6L9T8|FAM72D
     1  MSTNICSFKD RCVSILCCKF CKQVLSSRGM KAVLLADTEI DLFSTDIPPT NAVDFTGRCY
    61  FTKICKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNRH FWMFHSQAVY DINRLDSTGV
   121  NVLLRGNLPE IEESTDEDVL NISAEECIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM72D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
6.2 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 6.2 nTPM
  • lymph node: 4.5 nTPM
  • tonsil: 4.3 nTPM
  • bone marrow: 3.7 nTPM
  • appendix: 2.7 nTPM
  • testis: 2 nTPM

Single-cell type

  • late primary spermatocytes: 15 nCPM
  • early primary spermatocytes: 14 nCPM
  • monocyte progenitors: 8.7 nCPM
  • differentiating spermatogonia: 7.8 nCPM
  • extravillous trophoblasts: 7.2 nCPM
  • enteric transient amplifying cells: 5.4 nCPM

Immune cell

  • intermediate monocyte: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • T-reg: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • hypothalamus: 1.7 nTPM
  • midbrain: 1.6 nTPM
  • cerebellum: 1.5 nTPM
  • medulla oblongata: 1.5 nTPM
  • pons: 1.4 nTPM
  • thalamus: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0.03
gnomAD missense Z
0.69

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM72D as an antibody target. Whether an autoantibody or antibody against FAM72D could matter depends on whether native FAM72D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM72D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM72D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM72D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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